Long term ketamine effects

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Rationale: Ketamine is an N-methyl-d-aspartate NMDA -receptor antagonist that is increasingly being used as a recreational drug. research has shown gross generalised verbal memory impairments persisting 3 days after ketamine use in chronic users, however episodic memory has not specifically investigated in this population. Objective: To determine whether ketamine, on the night of drug use day 0 and 3 days later, is associated with impaired episodic memory as assessed by a source memory task.

Methods: Twenty ketamine users and 20 poly-drug controls were compared on a source memory task both on day 0 and 3.

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Participants also completed questionnaires on both days indexing schizophrenic-like and dissociative symptoms. : On day 0, ketamine abusers were impaired on both source memory and item recognition and scored more highly on schizophrenic and dissociative symptom scales compared to poly-drug controls. On day 3 ketamine abusers only displayed source memory impairments and these positively correlated with the level of schizophrenic-like symptoms on day 0. No differences on day 3 in schizophrenic-like or dissociative symptoms were observed.

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Conclusions: Ketamine abusers exhibit a persisting deficit in source memory on day 3 but not in item recognition. These findings suggest that repeated use of ketamine produces chronic impairments to episodic memory. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable.

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of items displayed: 5 10 15 20 50 Create RSS Cancel. RSS Link Copy. Full text links Cite Display options Display options. Abstract Rationale: Ketamine is an N-methyl-d-aspartate NMDA -receptor antagonist that is increasingly being used as a recreational drug. Similar articles Beyond the K-hole: a 3-year longitudinal investigation of the cognitive and subjective effects of ketamine in recreational users who have substantially reduced their use of the drug.

Morgan CJ, et al. PMID: Ketamine use, cognition and psychological wellbeing: a comparison of frequent, infrequent and ex-users with polydrug and non-using controls. Consequences of chronic ketamine self-administration upon neurocognitive function and psychological wellbeing: a 1-year longitudinal study. Epub Nov Gras-Vincendon A, et al. Epub Mar 4. PMID: Review. Recent trends in the use of "club drugs": an Australian review.

Degenhardt L, et al. Subst Use Misuse. See all similar articles. Abbott JA, et al. Mol Pharmacol. Epub Jun Esketamine: a glimmer of hope in treatment-resistant depression. Kaur U, et al.

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Eur Arch Psychiatry Clin Neurosci. Cognitive profile of ketamine-dependent patients compared with methamphetamine-dependent patients and healthy controls. Wang LJ, et al. Psychopharmacology Berl. Epub Apr Dissociation of item and source memory in rhesus monkeys. Basile BM, et al. Li Y, et al. Front Pharmacol. See all "Cited by" articles. Publication types Comparative Study Actions. Research Support, Non-U. Gov't Actions. MeSH terms Adolescent Actions.

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Adult Actions. Analysis of Variance Actions. Chi-Square Distribution Actions. Female Actions. Humans Actions. Male Actions. Statistics, Nonparametric Actions. Time Factors Actions. Substances Illicit Drugs Actions. Ketamine Actions. Full text links [x] Elsevier Science. Copy Download.

Long term ketamine effects

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How Ketamine Abuse Can Lead to Long-Term Side Effects