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Medically reviewed by Drugs. Last updated on July 2, Clinical trials of 5-HTP conducted in various conditions have resulted in limited evidence suggesting a place in therapy for anxiety, depression, and neurological conditions in which a serotonin deficiency is a contributory factor. Recent clinical trials do not provide adequate dosing guidelines. The potential for serotonin syndrome exists with concomitant use of selective serotonin reuptake inhibitors SSRIs or monoamine oxidase inhibitors MAOIs.
Nausea and vomiting are the most common dose-related adverse events. Diarrhea, abdominal pain, mild headache, and sleepiness have also been reported. There is little information on the toxicology of 5-HTP. A possible association with fatal eosinophilia-myalgia syndrome in the s and s has now been attributed to contaminated L-tryptophan.
Seeds from the woody climbing shrub G. The plant can grow to 3 m and is found in tropical Africa, most prevalently in Ghana. It has brown-black branches with simple, large, alternate leaves. The whole plant is used in African traditional medicine. The pulped bark is used topically on syphilitic sores, and a paste made from the leaves is applied to burns. The leaf sap is used for inflamed eyes, while decoctions made from the stem and leaves are used as a purgative, to relieve constipation, and as a topical antiseptic. Chewing the stems is said to provide an aphrodisiac effect, and the leaves are regarded as a good food source for animals.
The leaves of the plant have a high protein content and contain phosphorus and calcium, as well as a volatile 5 htp maximum daily dosage, coumarins, and 5-HTP and 5-hydroxytryptamine. Tryptophan, an essential amino acid, is obtained from animal protein in a Western diet. It is enzymatically converted to 5-HTP by tryptophan hydroxylase, which is further converted to serotonin. Factors that may influence the rate-limiting hydroxylase step in 5-HTP production include stress, insulin resistance, vitamin B 6 deficiency, and insufficient magnesium.
Studies in animals have found both inhibitory effects and heightened aggression with increased serotonin consequent to 5-HTP supplementation. Variables include the animal species used, length of treatment, and type of aggression. Clinical studies are lacking. Oral administration of an extract of G. Studies in healthy volunteers found that oral administration of 5-HTP reduced the incidence of induced panic and associated symptoms 5 htp maximum daily dosage compared with placebo.
The effect of 5-HTP persisted in the majority of participants at the 6-month end point.
Studies in rats found decreased food intake and loss of weight with administration of G. Decreased appetite and a decrease in mean body mass index were demonstrated at 4 weeks. Studies in rodents have demonstrated the effect of 5-HTP on circulating serotonin levels and in sleep deprivation. Additionally, serotonin syndrome can be induced in rats given 5-HTP.
Approximately 30 clinical trials in depression have been conducted since the s using 5-HTP. Following the occurrence of fatal eosinophilia associated with L-tryptophan and the advent of SSRIs, clinical studies were largely abandoned. However, the trials used small s of participants, and the de of the trials, dosages, and duration were heterogeneous, making a meta-analysis impossible.
A randomized, double-blind comparator trial in 60 patients in India with first episode depression found no statistically ificant difference in treatment response between groups treated 5 htp maximum daily dosage 5-HTP compared to fluoxetine. No ificant difference was observed in adverse effects between groups. Nausea, anorexia, and headache were the most commonly reported effects in both groups with insomnia also common with fluoxetine.
Limited clinical studies were conducted in the s.
However, in the 2-week period after treatment was stopped, a decrease in of days with headache was observed. A difference over placebo was found for consumption of analgesics. One hour after oral administration of 5-HTP mg or placebo, both healthy and irritable bowel syndrome IBS patients received a 1. Overall, oral 5-HTP administration resulted in pronounced alterations in mucosal serotonin metabolism in IBS patients but without reinforcement of the intestinal barrier function that was observed in healthy controls. A clinical trial evaluated the efficacy of 5-HTP mg daily in the frequency of hot flashes, finding no difference over placebo.
Reviews of studies using 5-HTP 5 htp maximum daily dosage degenerative ataxia and pediatric neurotransmitter diseases suggest a potential role in reducing neurological symptoms; however, inconsistent findings have been reported.
The testing method used indicated that exogenous 5-HTP effected forebrain dopamine synthesis, thereby reducing execution time to complete tasks. Continual nocturnal muscle spasms secondary to opioid withdrawal in a year-old female were relieved with 5 htp maximum daily dosage supplementation initiated at mg and followed by mg nightly until symptom improvement. The patient was intolerant to the side effects of clonidine, the cornerstone and only non-opioid treatment for opioid weaning.
Studies have been conducted in children range, 3 to 17 years of age. Information regarding safety and efficacy in pregnancy and lactation is lacking. Reports exist of serotonin syndrome consequent to L-tryptophan and fluoxetine combinations, but no reports to date can be attributed to 5-HTP.
Diarrhea, abdominal pain, bloating, mild headache, anorexia, and sleepiness have also been reported. Laboratory studies in rats have demonstrated a suppressive effect on sexual behavior with short-term doses of G.
Information regarding the toxicology of 5-HTP is lacking. A possible association with fatal eosinophilia-myalgia syndrome noted in the s and s has now been attributed to contaminated L-tryptophan. This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product.
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5-HTP: benefits, dosage and side-effects